Lead Exposure and Public Health: Prevention and Medical Treatment Strategies

Authors

Keywords:

Formative assessment, Autonomous learning, Educational feedback, Academic performance

Abstract

Lead exposure and its impact on public health: The use of lead dates back several millennia, and its exposure currently represents one of the most important challenges in the field of global public health. The World Health Organization (WHO) estimates that approximately 1.06 million deaths are associated with lead poisoning each year (WHO, n.d.). Although the harmful effects of lead are widely recognized, it continues to be used extensively in various industries, especially in the manufacturing of many products. Serum concentrations and clinical manifestations: Despite advances in toxicological knowledge, a safe threshold for lead in blood has not been established. However, it has been shown that adverse health effects usually occur when blood levels exceed 10 μg/dL in adults. In children, even considerably lower concentrations can trigger clinical symptoms of poisoning (WHO, n.d.). Symptoms are often nonspecific, making diagnosis difficult and requiring a high level of suspicion on the part of medical personnel. In cases of acute exposure, symptoms may include irritability, headache, abdominal discomfort, arthralgia, fatigue, acute kidney injury, and encephalopathy. The latter can progress to severe conditions such as delirium, seizures, and coma. On the other hand, chronic lead exposure can lead to conditions such as high blood pressure, chronic kidney disease, anemia, and alterations in neurocognitive development (WHO, n.d.).

References

Järup, L. (2003) Hazards of heavy metal contamination. British medical bulletin, 68(1), 167-182

Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B., y Beeregowda K. (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol, 7(2), 60- 72

Wani, L., Ara, A., y Usmani, J. (2015) Lead toxicity: a review. Interdiscip Toxicol, 8(2), 55-64.

Needleman, H. (2003) Lead poisoning. Annual review of medicine. 55: 209–222 Gilfillan, S. (1965) Lead poisoning and the fall of Rome. J Occup Med, 7:53-60.

Moore, M. (1977) Lead in drinking water in soft water areas--health hazards. Sci Total Environ,7(2):109-15.

Halmo L, Nappe TM. (2021) Lead Toxicity. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.

Caravanos, J., Dowling, R., & cols. (2014). Niveles de Plomo en Sangre en México y su Implicación para la Carga Pediátrica de la Enfermedad. Annals of Global Health, 80: 1-11

Azcona, M., Ramírez, R., y Vicente, G. (2015)Efectos tóxicos del plomo. Rev Esp Med Quir, 20:72-77

Alarcon, W.(2016) State Adult Blood Lead Epidemiology and Surveillance (ABLES) Program Investigators. Elevated Blood Lead Levels Among Employed Adults - United States, 1994-2013. MMWR Morb Mortal Wkly Rep,63(55):59-65.

Richter, P., Bishop, E., Wang, J., Swahn, M. (2009) Tobacco smoke exposure and levels of urinary metals in the U.S. youth and adult population: the National Health and Nutrition Examination Survey (NHANES) 1999-2004. Int J Environ Res Public Health, 6(7):1930-46.

He, Y., von Lampe, K., Wood, L., y Kurt, M. (2015) Investigation of lead and cadmium in counterfeit cigarettes seized in the United States. Food Chem Toxicol. 81: 40- 45

Kumar, A. (2020) Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches. Int J Environ Res Public Health, 17(7):2179

Bergeson, L. (2008) The proposed lead NAAQS: Is consideration of cost in the clean air act‘s future?. Wiley Online Library. 18:79–84.

Mitra, P., Sharma, S., Purohit, P., y Sharma, P. (2017) Clinical and molecular aspects of lead toxicity: An update. Crit Rev Clin Lab Sci, 54(7-8):506-528

Bent, J. (2017) Critical Care Toxicology: Diagnosis and Managment of the Critically Poisoned Patient. 2 ed. Springer

Merill, J., Morton, J., Soileau, S. (2007) Metals. In: Hayes A.W, editor. Principles and Methods of Toxicology. 5th ed.

Navas, A., Guallar, E., Silbergeld, E., Rothenberg, S. (2007) Lead Exposure and Cardiovascular Disease- A Systematic Review. Environmental Health Perspectives, 115 (3): 472-482

Ettinger, A., Egan, K., Homa, D., Brown, M. (2020) Blood Lead Levels in U.S. Women of childbearing Age, 1976-2016. Environmental Health Perspectives.128 (1): 1-9

Renzetti, S., Just, C., Burris, H., Oken, E., Amarasiriwardena, C., Svensson, K., Mercado- García, A., Cantoral, A., Schnaas, L., Baccarelli, A., Wright, R., Téllez-Rojo, M. (2017) The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort. Environ Res.152:226-232.

Ossiander, E. (2013) A systematic review of screening questionnaires for childhood lead poisoning. J Public Health Manag Pract. 19(1):E21-9.

Recall of Lead Care Blood Lead Tests due to risk of falsely low results. Health Alert Network. Centers for Disease Control and Prevention. https://emergency.cdc.gov/han/2021/han00445.asp

Update: Expansion of recall of LeadCare blood lead tests due to risk of falsely low results. Health Alert Network. Centers for Disease Control and Prevention. https://emergency.cdc.gov/han/2021/han00457.asp?ACSTrackingID=USCDC_5 11-DM69702&ACSTrackingLabel=HAN%20457%20-

%20General%20Public&deliveryName=USCDC_511-DM6970 Valdivia, M. (2005). Lead poisoning. Rev. Soc. Per. de Med. Inter.18(1) : 22-27.

Abadin, H., Ashizawa, A., Stevens, Y., Llados, F., Diamond, G., Sage, G., Citra, M., Quinones, A., Bosch, S., Swarts, S.(2007) Toxicological Profile for Lead. Atlanta (GA): Agency for Toxic Substances and Disease Registry (US)

Center for Disease Control and prevention. Recommended action based on blood lead level: summary of recommendations por follow-up and case management of children based on initial screening capillary and confirmed* venous blood lead levels. Extraído de: https://www.cdc.gov/nceh/lead/Advisory/acclpp/action- blls.htm

Baum, C., Hauptman, M., Newman, N., Woolf, A. (2021) Recommendations on management of childhood lead exposure: A resource for health professionals. Pediatric Environmental Health Specialty Units and the American Academy of Pediatrics. Extraído de: https://www.pehsu.net/_Library/facts/PEHSU_Fact_Sheet_Lead_Management_ Health_Professionals_Final.pdf

Goldman, R., & Hu, H. (2020) Lead exposure and poisoning in adults. UpToDate

Kosnett, M., Wedeen, R., Rothenberg, S., Hipkins, K., Materna, B., Schwartz, B., Hu, H., Woolf, A. (2007) Recommendations for medical management of adult lead exposure. Environ Health Perspect.115(3):463-71.

National Center for Biotechnology Information. (2021) PubChem Annotation Record for Lead, elemental, Source: Hazardous Substances Data Bank (HSDB). https://pubchem.ncbi.nlm.nih.gov/source/hsdb/231#section=Human-Toxicity- Excerpts-(Complete).

Downloads

Published

2023-01-30

How to Cite

Vélez Saltos, S. S. (2023). Lead Exposure and Public Health: Prevention and Medical Treatment Strategies. Sapiens Sciences, 1(1), e-11001. https://ssij.journalsapiens.org/index.php/ssj/article/view/48

Similar Articles

1-10 of 13

You may also start an advanced similarity search for this article.